Bioactive Small Molecules
Cayman Chemical ANTIBODY AmcasertIb 1mg
An inhibitor of cancer stem cells; inhibits the growth of HT-29 and MDA-MB-231 cancer cells (IC50s = 100-250 nM for both); exhibits a 2-fold increase in potency for a population of SW480 cells enriched for CSCs; reduces spherogenesis of CD44+-enriched FaDu cells; reduces tumor growth in PC3, HepG2, FaDu, and MKN45 mouse xenograft models when administered orally at a dose of 100 mg/kg; inhibits EGFR, C-MET, HER2, and PDGFRα in vitro without reducing global tyrosine kinase activity
Selleck Chemical LLC Celastrol 10mg 34157-83-0 Tripterine
Celastrol (Tripterine) is a potent proteasome inhibitor for the chymotrypsin-like activity of a purified 20S proteasome with IC50 of 2.5 ?M. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway. Celastrol inhibits dopaminergic neuronal death of Parkinson's disease through activating mitophagy. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical ANTIBODY BLX3887 1mg
A 15-LO-1 inhibitor (IC50 = 32 nM); selective for 15-LO-1 over 15-LO-2, which it does not inhibit, 5-LO (IC50 = 472 nM) and 12-LO (IC50 = 3,310 nM); inhibits endocytosis in, and the migration of, isolated human peripheral blood mononuclear cell-derived dendritic cells in vitro
TARGETMOL CHEMICALS INC ANTI-TB AGENT 1 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. anti-TB agent 1 is a potent and orally active anti-tuberculosis agent (MICs < 2 nM against the Mtb strains H37Rv rRMP and rINH). purity: 98%
Cayman Chemical ANTIBODY FngolImod 50mg
An immune modulator and a prodrug form of FTY720 phosphate; decreases the number of circulating lymphocytes in mice at 1 mg/kg; increases skin allograft survival in rats from 0.3-3 mg/kg; prevents disease development in a rat model of EAE; inhibits S1P lyase from 0.3-30 µM
Medchemexpress LLC 3,3'-Difluorobenzaldazine | 15332-10-2 | MFCD03653615 | 99.4% | 244.24 | C14H10F2N2 | 5 MG
3,3'-Difluorobenzaldazine (DFB) is a small-molecule research compound reported as a selective positive allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It is intended for preclinical and in vitro research and is characterized by defined molecular properties and high batch purity.
- Selective positive allosteric modulator of mGluR5.
- High purity suitable for research applications.
- Available in multiple small-scale pack sizes for screening and dose-response studies.
- Molecular formula C14H10F2N2; molecular weight 244.24.
- Supplied with batch-specific certificate of analysis for traceability.
Apexbio Technology LLC EPZ020411 hydrochloride 2070015-25-5 5mg
EPZ020411 hydrochloride (CAS 2070015-25-5) is a potent and selective inhibitor of protein arginine methyltransferase 6 (PRMT6) exhibiting an IC of approximately 10 nM By specifically inhibiting the catalytic activity of PRMT6 EPZ020411 hydrochloride reduces methylation at arginine 2 of histone H3 (H3R2) thereby modulating gene expression The compound demonstrates high selectivity with minimal inhibition of other PRMT family members resulting in reduced off-target activity EPZ020411 hydrochloride is utilized in research exploring the roles of PRMT6 in cancer inflammation and other disease models
Cayman Chemical ANTIBODY SAHA-d5 500ug
An internal standard for the quantification of SAHA by GC- or LC-MS
Medchemexpress LLC HY-N0518 5mg Medchemexpress, Toddalolactone CAS:483-90-9 Purity:>98%
Medchemexpress, HY-N0518 5mg Toddalolactone CAS:483-90-9 Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY BIIB-057 5mg
A potent, selective, orally bioavailable inhibitor of Syk (IC50 = 1 nM); blocks B cell receptor-mediated cell signaling and activation in whole blood (IC50s = 0.27 and 0.28 µM, respectively); inhibits inflammation and tumor growth in animal models of rheumatoid arthritis and non-Hodgkin lymphoma, respectively
Medchemexpress LLC Wehi-345 analog | 1354825-62-9 | 98.4% | 415.49 g·mol⁻¹ | C23H25N7O | 25 MG
WEHI-345 analog is a research-grade small molecule analogue of a RIPK2 kinase inhibitor supplied as a powder for biochemical and cellular studies of NOD signaling and NF-κB activation. Intended for laboratory research use only; follow the supplier's storage and handling recommendations.
- High purity suitable for research applications.
- Well-characterized chemical identity and molecular data.
- Powder form allows flexible formulation and dosing.
- Stable when stored under recommended conditions.
- Suitable for studying RIPK2-mediated signaling pathways.
Cayman Chemical 10Chloroestra1 4dIen3 17 5mg
A sterone ERα agonist; increases reporter gene expression in S. cerevisiae (EC50 = 0.36 nM for the human receptor); an aromatase inhibitor (IC50 = 2.4 µM)
Cayman Chemical FatostatInhydrobromIde 5mg
An inhibitor of SREBP activation, preventing SCAP-mediated escort of either SREBP-1 or SREBP-2 to the Golgi (IC50 = 5.6 µM); blocks SREBP-mediated gene expression; inhibits high glucose-induced upregulation of TGF-β in primary rat mesangial cells; reduces hepatic fat accumulation in ob/ob mice
Medchemexpress LLC DBCO-NHS ester 2 10mg | 1384870-47-6 | 430.45 g/mol | C25H22N2O5 | 10 MG
DBCO-NHS ester 2 is an amine-reactive dibenzocyclooctyne (DBCO) N-hydroxysuccinimide ester designed for efficient bioconjugation and copper-free click chemistry. It is provided as a small, research-scale solid with high reported purity and characterized molecular properties.
- Amine-reactive NHS ester for rapid conjugation to primary amines.
- DBCO handle enables copper-free strain-promoted azide-alkyne cycloaddition (SPAAC).
- Suitable for antibody, protein, and small-molecule labeling workflows.
- High purity supports reproducible conjugation and analytical characterization.
- Supplied as a compact solid quantity for research-scale experiments.
Cayman Chemical ANTIBODY ISCK03 25mg
A cell-permeable inhibitor of SCF-mediated c-kit activation, completely blocking phosphorylation of c-kit in human melanoma cells at a concentration between 1 and 5 µM; prevents SCF-mediated downstream phosphorylation of p44/p42 ERK